In the world of Bitotem live mysterious creatures called Bloods. Bloods are half animal and half human shapeshifters. After the death of her younger sister and disappearance of her father, a young White Tiger Blood named Kira sets off on a difficult journey to the Lion Blood Kingdom to murder King Andrew Kingsley for killing all of the Tiger Bloods left on Bitotem. She remains the last living Tiger Blood. On her expedition, she befriends Noah, a Wolf Blood, Ethan a Lion Blood and Chase an Eagle Blood.